structural biology: modeling applications and techniques at a glance

نویسندگان

mohammad reza abbaszadegan division of human genetics, immunology research center,avicenna research institute, mashhad university of medical sciences (mums),mashhad

morteza moghaddasian proteomics research center, shahid beheshti university of medical sciences, tehran

mostafa rezaei tavirani proteomics research center, shahid beheshti university of medical sciences, tehran

reza raeisossadati proteomics research center, shahid beheshti university of medical sciences, tehran

چکیده

as recent advancements in biology shows, the molecular machines specially proteins, rna and complex molecules play the main role of the so called cell functionality. it means a very big part of the system biology is concerned with the interactions of such molecular components. drug industries and research institutes are trying hard to better understand the concepts underlying these interactions and are highly dependent on the issues regarding these molecular elements. however the costs for such projects are so high and in many cases these projects will be funded by governments or profit making companies. with this in mind it has to be said that the techniques like stimulation are always a very good candidate to decrease such costs and to provide scientists with a bright future of the project results before undergoing costly experiments. however the costs involved projects that determine an approximation for the problem is not that much high but they are also costly. so it is of utmost importance to invent special techniques for the concept of stimulation that can also decrease the project costs and also predict much accurately. since the system biology and proteomics as the study of the proteins and their functions are in the center of consideration for the purpose of drug discovery, understanding the cell functionalities and the underlying causes behind diseases; so we need advance software and algorithms that can predict the structure of the molecular components and to provide researchers with the computational tools to analyze such models. in this paper we make review of the importance of molecular modeling, its limitations and applications.

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عنوان ژورنال:
journal of paramedical sciences

جلد ۴، شماره ۱، صفحات ۰-۰

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